Epidemiological study from MP pneumonia and you may RWE from 2003 so you can 2014
Mathematical data
All calculations were performed with SPSS V.14.0 (SPSS Inc.)parisons between groups were performed using the Student’s t-test, ? 2 test and Fisher’s exact test, and the data were expressed as mean±SD for continuous variables. A p value of <0.05 was considered statistically significant.
Performance
The fresh sufferers in today’s studies was in fact 793 customers with MP pneumonia and you will 384 customers with RWE within the studies period. To possess epidemiological comparison, an entire 793 clients were utilized, as shown for the prior to now wrote blog post.14 To have scientific investigations between the teams, all in all, 501 MP pneumonia people that have been acknowledge through the brand new current epidemics (241 cases inside 2007–2006, and you can 260 cases last year), and you may 384 customers which have RWE have been analysed (figure step 1). Inside study period, the entire quantity of acknowledge people at all of our service try good complete twenty five 911 (except garden center patients). There had been whenever 2100 admitted patients a-year which includes distinctions during the yearly.
Most of MP pneumonia customers had pursue-upwards period no less than three years away from history epidemic 12 months away from 2011, however the pursue-right up victims satisfied with our solutions requirements was basically 180 certainly one of 501 cases about MP pneumonia class and you may 206 certainly one of 384 circumstances regarding the RWE class.
Into the MP pneumonia customers, there have been clear episodes off cases in the 2003, 2006–2007 and you may 2011, with some cases taking place regarding interepidemic episodes. There are apparently regular quantities of RWE times yearly during the the analysis period. There have been no involved increased instances in the MP pneumonia epidemic years except when you look at the 2007 (shape dos). No MP pneumonia patient who was readmitted due to MP reinfection along the epidemics are observed while in the study several months. Brand new indicate decades and you can age delivery was equivalent, additionally the peak age range had been 2–5 years of age in both organizations (contour step three). When you look at the seasonality of both organizations, MP pneumonia was common inside coming down acquisition from trip, june, winter and you will spring season, when you are clients that have RWE was indeed very commonplace into the autumn, followed by spring season, wintertime and you will june (investigation perhaps not shown).
Market and medical characteristics out of MP pneumonia and you can RWE teams
Demographic, clinical and laboratory data in both groups are shown in table 1. The mean age and age distribution were similar in both groups as shown in figure 3 (5.4 years vs 5.6 years, p=0.312). Both groups had male predominance, and there were more males in the RWE group. As expected, cases with wheezing at presentation, the proportion of patients with history or family history of allergic diseases, and history of wheezing were higher in the RWE group. Recurrent wheezing after discharge was observed in 38 of 180 patients with MP pneumonia and 141 of the 206 patients with RWE (p<0.001).
In MP pneumonia patients, 52 of the total 501 patients (10.4%) had wheezing at presentation, 72 (14.4%) had a history of allergic diseases, 15 (3%) had RWE according to our definition and 40 (8%) had a family history of allergic diseases. When we divided the MP pneumonia patients into two groups of patients with wheezing (n=52) and without wheezing (n=449), the patients with wheezing were younger (3.7 years vs 5.6 years, p<0.001) and had higher proportions of history allergic diseases and wheezing history and higher values of leucocyte count and eosinophil differential (table 2). Among the 52 MP pneumonia patients with wheezing at admission, 10 were patient with RWE, while 42 had no previous RWE history. Thus, in this study, 66% (10 of 15) of patients with RWE history presented with wheezing, while 8.6% of patients without RWE history (42 of 486) had wheezing at presentation. In a follow-up study of patients who visited two or more times after discharge, 13 (including 5 cases of RWE) of 21 MP pneumonia patients with initial wheezing and 25 (including 2 cases of RWE) of 159 MP pneumonia patients without wheezing had at least one wheezing episode after discharge (table 2). Although not all patients were followed-up, it was estimated that at least 31 of the total MP pneumonia patients (n=501, 6.2%) showed a recurrent wheezing after initial MP infection.
